Title: Synthesis, characterization and pharmacological studies of some ethoxyphthalimide derivatives of thiazolo[4,5-d]pyrimidines and thiazolo[4,5-c]isoxazoles


Authors:

Swati Joshi

swtojha@gmail.com
Department of Chemistry, Swami Keshvanand Institute of Technology, Management & Gramothan, Jaipur, India,

Usha Ameta

ijskit@skit.ac.in
Department of Chemistry, M. L. Sukhadia University, Udaipur, India,

GL Talsera

ijskit@skit.ac.in

Pages: 86-94

DOI:

Abstract:

 A number of 3-N-ethoxyphthalimido-5-amino-2-oxo- 7-(substituted  phenyl/2-furyl) -1,3-thiazolo[4,5-d]pyrimidines [5a-f] and  6-N-ethoxyphthalimido-5-oxo 3-(substituted phenyl/2-furyl)- 3,3a-dihydro[1,3]thiazolo[4,5-c]isoxazoles [7a-f] have been synthesized from the condensation of phthalimidoxyethyl bromide with  [4a-f] and [6a-f], respectively. The compounds [4a-f] and [6a-f] in turn have been prepared by the reaction of 5-(substituted phenyl/2-furyl)-1,3-thiazolidine-2,4-dione [3a-f] with guanidine nitrate and hydroxylaminehydrochloride, respectively. The structure of compounds was established by elemental analysis and spectral data.  All the newly synthesized compounds have been assayed for their antibacterial activities against B. subtilis, K. pneumoniae, E. coli and P. mirabilis and antifungal activities against A. fumigatus and C. albicans.

Keywords:
Iminothiazolidinone, Cyclisation, Condensation, Alkoxyphthalimides